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Tirofiban hydrochloride monohydrate

CAS No. 150915-40-5

Tirofiban hydrochloride monohydrate ( L-700462;MK-383;MK-0383 )

Catalog No. M12110 CAS No. 150915-40-5

A potent, selective inhibitor of the platelet fibrinogen receptor GPIIb/IIIa with IC50 of 9 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Tirofiban hydrochloride monohydrate
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective inhibitor of the platelet fibrinogen receptor GPIIb/IIIa with IC50 of 9 nM.
  • Description
    A potent, selective inhibitor of the platelet fibrinogen receptor GPIIb/IIIa with IC50 of 9 nM, inhibition of platelet aggregation; displays > 24,000-fold over human umbilical vein endothelial cell fibrinogen receptors; inhibits ex vivo platelet aggregation induced by ADP in anesthetized dogs.Thrombosis Approved
  • Synonyms
    L-700462;MK-383;MK-0383
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Integrin
  • Recptor
    GPIIb/IIIa
  • Research Area
    Cardiovascular Disease
  • Indication
    Thrombosis

Chemical Information

  • CAS Number
    150915-40-5
  • Formula Weight
    495.07
  • Molecular Formula
    C22H39ClN2O6S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 12 mg/mL
  • SMILES
    CCCCS(=O)(=O)N[C@@H](CC1=CC=C(C=C1)OCCCCC2CCNCC2)C(=O)O.O.Cl
  • Chemical Name
    L-Tyrosine, N-(butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-, hydrochloride, hydrate (1:1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hartman GD, et al. J Med Chem. 1992 Nov 27;35(24):4640-2.
2. Lynch JJ Jr, et al. J Pharmacol Exp Ther. 1995 Jan;272(1):20-32.
3. Cook NS, et al. Thromb Haemost. 1993 Nov 15;70(5):838-47.
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